Rotating monomer causes BUNS.

Case number:671071-2011582
Topic:Game: Other
Opened by:BootsMcGraw
Opened on:Sunday, May 16, 2021 - 20:29
Last modified:Monday, May 17, 2021 - 16:42

I've brought this up, before, without a satisfactory solution.

Why is it that when I rotate a monomer about one of its own axes, I suddenly introduce one, two, even three BUNS that were not there, before? I don't have the monomer anywhere near its counterparts... I'm just trying to get a better view of what I have. Why does that cost me up to six hundred points?

(1992, and every other trimer/tetramer puzzle I've played.)

(Sun, 05/16/2021 - 20:29  |  1 comment)

bkoep's picture
User offline. Last seen 16 hours 32 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff

Yes, this is a known issue, and we currently have no prospect of a fix, unfortunately.

In short, this rotational instability is the price we pay for performance. It comes down to surface area calculations, which are computationally expensive. In order for the BUNS Objective to run in "real time" while you manipulate the protein model, we use a cheaper calculation to approximate the surface area calculations. This alternative is much faster, but it is also sensitive to rotation and translation of the model in 3D space.

At some point in the future, we may revisit this to see if we can make the more accurate calculation work. But that has some considerable development cost, and currently has lower priority than some other work we'd like to do.


Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons