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1991: TGF Receptor Binder Design: Round 3
Status: Closed
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Evolvers
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| 1 | ZeroLeak7 70 62 | Go Science | 10,882 | 100 | | 2 | mirp 13 17 | Go Science | 10,824 | 96 | | 3 | toshiue 1 39 | Go Science | 10,806 | 92 | | 4 | silent gene 6 8 | Go Science | 10,785 | 88 | | 5 | argyrw 25 84 | Go Science | 10,724 | 85 | | 6 | kyoota 9 42 | Go Science | 10,719 | 81 | | 7 | Bruno Kestemont 3 4 | Go Science | 10,707 | 78 | | 8 | NinjaGreg 21 14 | Go Science | 10,658 | 74 | | 9 | Keresto 44 337 | Gargleblasters | 10,545 | 71 | | 10 | LociOiling 4 1 | Beta Folders | 10,495 | 68 | | 11 | Angus 24 77 | Beta Folders | 10,490 | 65 | | 12 | Galaxie 2 3 | Anthropic Dreams | 10,430 | 62 | | 13 | mbinfield 55 604 | Go Science | 10,370 | 59 | | 14 | Bletchley Park 10 40 | Contenders | 10,290 | 56 | | 15 | georg137 20 38 | Contenders | 10,290 | 54 | | 16 | alcor29 5 13 | Anthropic Dreams | 10,275 | 51 | | 17 | robgee 8 10 | Anthropic Dreams | 10,211 | 49 | | 18 | BootsMcGraw 15 9 | Contenders | 10,124 | 46 | | 19 | phi16 11 23 | Anthropic Dreams | 9,966 | 44 | | 20 | jausmh 16 32 | Marvin's bunch | 9,308 | 42 | | 21 | mwm64 37 227 | Gargleblasters | 6,840 | 40 | Need this puzzle? Log in to download.
Comments
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DDG Metric (max +2000)
The predicted binding energy of your design. The goal DDG is -40.0 or less.
Contact Surface (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 500 or more.
Buried Unsats (max +500)
Penalizes 100 points for each polar atom that cannot make any hydrogen bonds.
Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.
Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
SS Design (max +500)
Disabled use of CYS residues. Penalizes GLY, ALA residues in sheets and helices.