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1991: TGF Receptor Binder Design: Round 3
Status: Closed
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Evolvers
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| 1 | ZeroLeak7 45 147 | Go Science | 10,882 | 100 | | 2 | mirp 45 1456 | Go Science | 10,824 | 96 | | 3 | toshiue 45 860 | Go Science | 10,806 | 92 | | 4 | silent gene 23 65 | Go Science | 10,785 | 88 | | 5 | argyrw 40 280 | Go Science | 10,724 | 85 | | 6 | kyoota 11 40 | Go Science | 10,719 | 81 | | 7 | Bruno Kestemont 2 2 | Go Science | 10,707 | 78 | | 8 | NinjaGreg 37 14 | Go Science | 10,658 | 74 | | 9 | Keresto 41 430 | Gargleblasters | 10,545 | 71 | | 10 | LociOiling 3 1 | Beta Folders | 10,495 | 68 | | 11 | Angus 45 1456 | Beta Folders | 10,490 | 65 | | 12 | Galaxie 1 3 | Anthropic Dreams | 10,430 | 62 | | 13 | mbinfield 45 1456 | Go Science | 10,370 | 59 | | 14 | Bletchley Park 8 7 | Contenders | 10,290 | 56 | | 15 | georg137 18 35 | Contenders | 10,290 | 54 | | 16 | alcor29 5 9 | Anthropic Dreams | 10,275 | 51 | | 17 | robgee 7 6 | Anthropic Dreams | 10,211 | 49 | | 18 | BootsMcGraw 10 8 | Contenders | 10,124 | 46 | | 19 | phi16 9 28 | Anthropic Dreams | 9,966 | 44 | | 20 | jausmh 17 30 | Marvin's bunch | 9,308 | 42 | | 21 | mwm64 44 326 | Gargleblasters | 6,840 | 40 | Need this puzzle? Log in to download.
Comments
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DDG Metric (max +2000)
The predicted binding energy of your design. The goal DDG is -40.0 or less.
Contact Surface (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 500 or more.
Buried Unsats (max +500)
Penalizes 100 points for each polar atom that cannot make any hydrogen bonds.
Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.
Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
SS Design (max +500)
Disabled use of CYS residues. Penalizes GLY, ALA residues in sheets and helices.