puzzle picture
1986: Biotin Ligand Binder Design
Status: Closed

Groups



Need this puzzle? Log in to download.  

Comments

bkoep's picture
User offline. Last seen 2 days 7 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Contact Surface Metric (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 200 or more.

Buried Unsats (max +500)
Penalizes 100 points for each polar atom that cannot make any hydrogen bonds.

OWM3's picture
User offline. Last seen 23 weeks 1 day ago. Offline
Joined: 03/08/2020
Groups: Gargleblasters
The puzzle looks broken.

The puzzle looks broken.

OWM3's picture
User offline. Last seen 23 weeks 1 day ago. Offline
Joined: 03/08/2020
Groups: Gargleblasters
Whatever

You may ignore this comment, I had to restart my foldit instance to fix a damn glitch :)

spdenne's picture
User offline. Last seen 3 weeks 1 day ago. Offline
Joined: 10/01/2011
Groups: Void Crushers
This puzzle crashes (on windows)

****** Encountered Crash at ..\..\..\source\src\core\chemical\ResidueType.cc:4071
unknown atom_name: ' CA ' in residue BTN

milkshake's picture
User offline. Last seen 16 weeks 4 days ago. Offline
Joined: 07/17/2019
Groups: Foldit Staff
Thanks

Thank you spdenne, we have a lead on how to fix this.

milkshake's picture
User offline. Last seen 16 weeks 4 days ago. Offline
Joined: 07/17/2019
Groups: Foldit Staff
In the meantime, disabling

In the meantime, disabling the view option "Show backbone issues" should prevent the crash.

spdenne's picture
User offline. Last seen 3 weeks 1 day ago. Offline
Joined: 10/01/2011
Groups: Void Crushers
Thank you

for the work-around

spvincent's picture
User offline. Last seen 5 hours 20 min ago. Offline
Joined: 12/07/2007
Groups: Contenders
Its hard to do much redesign

Its hard to do much redesign when you can't add or delete segments.

bkoep's picture
User offline. Last seen 2 days 7 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
That's good to know!

We probably don't want to allow extra residues in these puzzles. But in future puzzles we should be able to allow deletions and re-insertions.

User login
Download links:
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.12 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Social Media


Search
Only search fold.it
Other Games: Mozak
Recommend Foldit
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons