puzzle picture
1985: TGF Receptor Binder Design: Round 2
Status: Closed

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RankGroupScorePoints
1Beta Folders10,582100
2Gargleblasters10,51165
3Anthropic Dreams10,47541
4Go Science10,38024
5Contenders10,11514
6Void Crushers9,3667
7Marvin's bunch9,1714
8Australia8,5622
9Team China8,4291
10L'Alliance Francophone8,2531
11BOINC@Poland7,9251
12Italiani Al Lavoro7,1561
13Czech National Team6,8061


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bkoep's picture
User offline. Last seen 16 hours 5 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

DDG Metric (max +2000)
The predicted binding energy of your design. The goal DDG is -40.0 or less.

Contact Surface Metric (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 500 or more.

Buried Unsats (max +500)
Penalizes 100 points for each polar atom that cannot make any hydrogen bonds.

Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Disabled use of CYS residues. Penalizes GLY, ALA residues in sheets and helices.

Joined: 10/18/2021
Groups: None
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons