puzzle picture
1979: TGF Receptor Binder Design: Round 1
Status: Closed

Groups

RankGroupScorePoints
1Go Science10,729100
2Anthropic Dreams10,66473
3Contenders10,60552
4Gargleblasters10,20336
5Beta Folders10,13424
6Marvin's bunch10,09016
7Void Crushers9,55110
8BOINC@Poland9,5146
9Australia9,1554
10Olsztynek7,8342
11Italiani Al Lavoro7,7411
12Team China7,6401
13Hold My Beer7,1471
14L'Alliance Francophone6,5651
15Czech National Team6,0431
16Mojo Risin'5,6431
17Richard Dawkins Foundation3,2801


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bkoep's picture
User offline. Last seen 21 hours 20 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

DDG Metric (max +2000)
The predicted binding energy of your design. The goal DDG is -40.0 or less.

Contact Surface Metric (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 500 or more.

Buried Unsats (max +500)
Penalizes 100 points for each polar atom that cannot make any hydrogen bonds.

Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Disabled use of CYS residues. Penalizes GLY, ALA residues in sheets and helices.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons