puzzle picture
1973: Tie2 Binder Design: Round 1
Status: Closed

Groups

RankGroupScorePoints
1Go Science10,003100
2Contenders9,77976
3Beta Folders9,72956
4Anthropic Dreams9,68841
5Marvin's bunch9,48029
6Void Crushers9,41920
7Gargleblasters9,38814
8BOINC@Poland8,9839
9L'Alliance Francophone8,6106
10Australia8,4124
11Olsztynek7,7212
12Team China7,3951
13Italiani Al Lavoro6,5941
14Coastal Biochemistry5,4051
15FoldIt@Netherlands5,2101
16Czech National Team4,9911
17SETI.Germany3,5991
18Trinity Biology1,9301
19Window Group01


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Comments

bkoep's picture
User offline. Last seen 13 hours 37 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

DDG Metric (max +2000)
The predicted binding energy of your design. The goal DDG is -40.0 or less.

Contact Surface Metric (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 400 or more.

Buried Unsats (max +500)
Penalizes 100 points for each polar atom that cannot make any hydrogen bonds.

Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Disabled use of CYS residues. Penalizes GLY, ALA residues in sheets and helices.

nspc's picture
User offline. Last seen 13 hours 52 min ago. Offline
Joined: 03/26/2020
Groups: Go Science
objective

Like 1968, maybe we need like a score objective to know when it is time to share and create a new solution.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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