puzzle picture
Beginner Puzzle (<150): Coronavirus
Status: Closed

Summary

Name: Beginner Puzzle (<150): Coronavirus
Status: Closed
Created: 03/03/2020
Points: 100
Expired: 05/13/2021 - 23:00
Difficulty: Beginner
Description: Design a protein binder against coronavirus! The starting structure shows how the coronavirus spike protein binds to a human receptor protein. The coronavirus protein (in gray) is mostly frozen, except for the orange and blue sidechains at the binding site. The binding site of coronavirus sticks to the human protein (in color), and this allows the coronavirus to infect human cells. We want to design a new protein that can bind to coronavirus more tightly than the human protein! A tight binder could block the normal coronavirus-human interaction, and might be used as an antiviral drug against coronavirus! Refold and mutate the starting structure to increase your score and improve binding against coronavirus!

START HERE:

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864
_____________________________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :
- try all puzzles not only "Beginners" ones,
- fold first the ones you like the most,
- try it by yourself to understand what works and what doesn't,
- ask for tips in global chat when you think you don't understand something.

Categories: Beginner

Top Groups

RankGroupScorePoints
1Go Science13,726100
2Gargleblasters13,69287
3L'Alliance Francophone13,47275
4Italiani Al Lavoro13,39964
5Czech National Team13,26655

Top Soloists

RankPlayerGroupScorePoints
1wolekw 70 79  13,916100
2HurryPeng 70 163  13,737100
3JinchaoHuang 70 114  13,72399
4Terrifive 70 123  13,71898
5abiogenesis 70 63 Go Science13,71097


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Comments

Dudit's picture
User offline. Last seen 2 hours 20 min ago. Offline
Joined: 12/26/2016
Groups: Go Science
Tips for Beginners Coronavirus Puzzle

Steps:
1. Start at Low Wiggle Power at Clashing Importance of 0.33 -> 0.66 -> 1.00
2. Medium Wiggle Power at Clashing Importance of 1.00
3. Auto Wiggle Power at Clashing Importance of 1.00

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons