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Beginner Puzzle (<150): Coronavirus
Status: Closed


Name: Beginner Puzzle (<150): Coronavirus
Status: Closed
Created: 03/03/2020
Points: 100
Expired: 05/13/2021 - 23:00
Difficulty: Beginner
Description: Design a protein binder against coronavirus! The starting structure shows how the coronavirus spike protein binds to a human receptor protein. The coronavirus protein (in gray) is mostly frozen, except for the orange and blue sidechains at the binding site. The binding site of coronavirus sticks to the human protein (in color), and this allows the coronavirus to infect human cells. We want to design a new protein that can bind to coronavirus more tightly than the human protein! A tight binder could block the normal coronavirus-human interaction, and might be used as an antiviral drug against coronavirus! Refold and mutate the starting structure to increase your score and improve binding against coronavirus!


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Categories: Beginner

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Dudit's picture
User offline. Last seen 1 day 3 hours ago. Offline
Joined: 12/26/2016
Groups: Go Science
Tips for Beginners Coronavirus Puzzle

1. Start at Low Wiggle Power at Clashing Importance of 0.33 -> 0.66 -> 1.00
2. Medium Wiggle Power at Clashing Importance of 1.00
3. Auto Wiggle Power at Clashing Importance of 1.00

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons