bkoep's picture
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Joined: 11/15/2012
Groups: Foldit Staff
Objectives

DDG Metric (max +2000)
The predicted binding energy of your design. The goal DDG is -40.0 or less.

Contact Surface Metric (max +2000)
Measures how much of your binder surface is in close contact with the target protein. The goal Contact Surface is 400 or more.

Buried Unsats (max +500)
Penalizes 100 points for each polar atom that cannot make any hydrogen bonds.

Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Disabled use of CYS residues. Penalizes GLY, ALA residues in sheets and helices.

Joined: 12/06/2008
Groups: Contenders
Leaderboard for acceptable solutions?

Is their going to be a scoreboard posted, showing how many 10000-point solutions the players have made? After all, this is a competition, and we'd like to know how our competitors are doing. (And we like to see our names in print.)

bkoep's picture
User offline. Last seen 12 hours 23 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
No realtime updates

Unfortunately, we don't have a way to update the competition status continuously in realtime. We will plan to post an interim report after the first week of the two-week competition. I may also be able to post more frequent updates here in the puzzle comments (but no guarantees!).

I agree that this is not ideal, and I wish the Foldit website were set up to show this data in real time! One of the goals of this "pilot" competition is to determine whether we should divert resources to actually implement a different reward system. That will require a non-trivial amount of work, and we don't want to demote our other priorities unless we think it will be worth it.

So far, I can tell you that nobody has submitted more than one solution!

Joined: 12/06/2008
Groups: Contenders
"Unknown" AA at position 13?

Wondering why segment 13 is "unknown", using "X" as its sidechain.

No one knows what it is? Or is it variable, and it doesn't matter what the sidechain is?

https://ibb.co/K0WW7tf

bkoep's picture
User offline. Last seen 12 hours 23 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Glycosylation

Residue 13 is an ASN that is glycosylated, meaning that a sugar polymer is attached to the ASN sidechain after the protein is translated by the ribosome. In Foldit, the glycosylated ASN is treated like a special residue under the hood, with an undefined name and one-letter code, so it may appear as "unknown" or "X" in some Foldit tools.

See this previous comment for more details about the glycan.

Joined: 05/03/2009
Groups: Contenders
Just for a little clarity

Evening all

Can you be a little more specific, regarding what constitutes a valid 10k score. Does the chain of evidence have to include every move I make from the moment I reset and start afresh to the moment I 'submit for scientists'? Can I reload an interim quickslot if one direction didnt pan out? And what if I crash, can I rescue the last move and still be able to submit when I breach 10k?

Cheers
CFC

bkoep's picture
User offline. Last seen 12 hours 23 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Yes!

Foldit will correctly handle the "chain of evidence" behind the scenes, even when Foldit crashes. Just restart Foldit and keep working with the latest autosave; you can submit this solution when it passes 10,000 points, and all of its history will remain intact.

If you have a solution with less than 10,000 points, you can undo or revert to an earlier stage of the solution and try another direction. The main thing is that you may not submit two solutions from the same restart. So, after you submit a solution with >10,000 points, you should avoid loading previous versions of that submitted solution.

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