1963: Two-sided Interface Design
|Name:||1963: Two-sided Interface Design|
|Expired:||03/10/2021 - 23:00|
|Description:||Design an interface between two protein chains! This puzzle starts with a fully-folded interface, but you will need to refold it in order to get credit. The Exploration Objective checks how closely your solution matches the starting structure, and any solution with RMSD < 3.0 A will not receive credit! We're hoping that Foldit players can find high-scoring variations on this starting structure. See the blog for more details.
In this two-sided design puzzle, you can mutate the interface residues of both chains A and B, but you may only shape the backbone of chain A. The goal is to create a binding interface between the two protein chains so that they will stick together in solution. However, the starting position of the two chains is important, so the locked regions are held in place by strong constraints. The only way to make the two chains bind will be to fold up a brand new interface between them.
As you build on chain A, it will be important to make a strong core so that it folds up correctly. It will also be important to have good hydrophobic packing at the interface where the two chains come together, so that they bind each other tightly. Players may add up to 40 additional residues at a cost of 55 points per residue. See the puzzle comments for Objective details.
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