Made disulfide bond on 1959 and got no bonus.

Case number:671071-2011264
Topic:Game: Other
Opened by:BootsMcGraw
Status:Closed
Type:Bug
Opened on:Friday, February 26, 2021 - 01:49
Last modified:Thursday, April 8, 2021 - 18:32

I made a disulfide bond between segments 46 (on my protein) and 84 (on target protein A) on puzzle 1959. I was given no bonus points for making a bond at the interface of the two chains.

Here's proof:

https://ibb.co/cw0SmD2

Please add 250 points to my soloist score when calculating global points for this puzzle.

(Fri, 02/26/2021 - 01:49  |  6 comments)


agcohn821's picture
User offline. Last seen 1 day 2 hours ago. Offline
Joined: 11/05/2019
Groups: Foldit Staff

Hi Boots! Thank you for the feedback!

Joined: 12/06/2008
Groups: Contenders

Odd. I made a disulfide bond between segment 9 (on my protein), and 161 (on target protein B), and I was awarded the 250 point bonus.

bkoep's picture
User offline. Last seen 12 hours 8 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff

Hi Boots, any chance you can share that first solution, via Upload for Scientists?

Joined: 12/06/2008
Groups: Contenders

Uploaded to scientists as "46/84 S/S bond no bonus".

bkoep's picture
User offline. Last seen 12 hours 8 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff

Ah I see. This is correct. The Disulfide Objective in Puzzle 1959 should only reward a disulfide bond that connects the two chains.

In your first solution, you created a good disulfide bond between two CYS residues, but both CYS residues were on the same chain. Since the disulfide did not connect the chains, it did not receive a bonus. In your second solution, one CYS is on chain A and the other CYS is on chain B. Since the disulfide connects the chains, it receives the bonus.

Sorry for the confusion! In the future, we'll try to be more clear about this in the puzzle description. Note that the above explanation applies only to Puzzle 1959. That is not always how the Disulfide Objective works; in many puzzles, it will indeed award a bonus for an intra-chain bond that connects two CYS residues on the same chain.

Joined: 12/06/2008
Groups: Contenders
Status: Open » Closed

Answered to my satisfaction. Closing old threads.

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