neilpg628's picture
User offline. Last seen 9 weeks 6 days ago. Offline
Joined: 08/01/2019
Groups: Foldit Staff
Objectives

Residue Count (max +250)
Penalizes extra residues inserted beyond the starting 260, at a cost of 25 points per residue beyond 270. Players may use up to 280 residues in total.

Core Existence: Linker (max +2400)
Ensures that at least 35 percent of residues are buried in the core of the linker unit.

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Prohibits CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

ContactMolecularSurface (max +700)
Checks that the designed linker has an energetically favorable interface with the binders.

Buried Unsats (max +500)
Penalizes polar atoms on the linker that cannot make hydrogen bonds, -60 points per atom.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons