puzzle picture
1954: Symmetric Tetramer Design: H-bond Networks
Status: Closed

Groups

RankGroupScorePoints
1Go Science19,890100
2Contenders19,50374
3Gargleblasters19,38954
4Anthropic Dreams18,83838
5Beta Folders18,71827
6Marvin's bunch17,65818
7L'Alliance Francophone16,16212
8Australia16,0008
9BOINC@Poland15,6205
10Void Crushers13,9503
11Coastal Biochemistry13,8392
12Olsztynek12,6251
13Trinity Biology11,8531
14Italiani Al Lavoro11,6901
15Biotechnology-105 (2020)8,7261
16CHM 232 Lab GVSU4,8841
17Foldit Staff01
18Window Group01


Need this puzzle? Log in to download.  

Comments

bkoep's picture
User offline. Last seen 11 hours 10 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -200 points per atom (not including symmetric copies).

Core Existence: Monomer (max +1600)
Ensures that at least 16 residues are buried in the core of the monomer unit.

Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.

H-bond Network (max +2400)
Rewards networks that comprise at least 2 H-bonds involving core residues.
Between 1 and 12 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

User login
Download links:
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.12 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Social Media


Search
Only search fold.it
Other Games: Mozak
Recommend Foldit
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons