Fri, 02/05/2021 - 14:29
Robust folding of a de novo designed ideal protein even with most of the core mutated to valine
Wed, 02/10/2021 - 17:25
#2
I've sort-of been doing this ...
but am astounded that there's an actual **theory** behind it!
As long as we're on the K&K track, there's also Consistency principle for protein design, which might be of interest.
Or there's the aardvark design principle, which is "change everything to aardvark, aardvark, aardvark, make helices, and hope for the best". (Still haven't gotten a complete aardvark yet, however.)