Why doesn't Blueprint tool make ideal loops between sheets?
|Opened on:||Monday, January 18, 2021 - 22:02|
|Last modified:||Tuesday, January 19, 2021 - 05:59|
I use the Blueprint tool to the exclusion of all others when I am first designing a protein. My latest (#1944) design has a 12-residue helix, plus five 5-residue sheets, plus another 12-residue helix. Each of the loops between these seven structures was also designed using the Blueprint tool.
I somehow have three un-ideal loops, all between the sheets. I have done nothing to the structure except to create it: no shake, no wiggle, no mutate. Nothing. Nada. Zip. Zilch. Why, then, if the Blueprint tool is supposed to provide us with ideal loops, do I have ANY un-ideal ones?