puzzle picture
1938: Symmetric Tetramer Design: H-bond Networks
Status: Closed


2Go Science24,53370
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7L'Alliance Francophone19,7547
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bkoep's picture
User offline. Last seen 21 hours 28 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff

Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -200 points per atom (not including symmetric copies).

Core Existence: Monomer (max +2800)
Ensures that at least 28 residues are buried in the core of the monomer unit.

Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.

H-bond Network (max +2400)
Rewards networks that comprise at least 2 H-bonds involving core residues.
Between 1 and 12 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

grogar7's picture
User offline. Last seen 20 hours 40 min ago. Offline
Joined: 10/03/2011
puzzle very crashy

A little late to be reporting this, perhaps, but Puzzle 1938 has been crashing regularly. This happens when scripts are running, and has been reported by other team mates as well. Tvdl Filter Mutate Combo 1.0.0 and Acid Tweeker are among the culprits. Unfortunately, I have not been able to catch this as it happens.
I start a script. It seems to be running normally. I walk away. I come back 15 minutes later and the client has disappeared.
Very frustrating!

bkoep's picture
User offline. Last seen 21 hours 28 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Thanks for letting us know!

The next time Foldit crashes, and before you restart Foldit, it would help if you could check the log.txt file for any error messages. Or you could open a new Feedback issue and just load the log.txt file and I'll be happy to take a look at it.

Of course, if you learn any more details about when the crash occurs, that will also help!

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons