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1935: Two-Sided Interface Design
Status: Closed

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bkoep's picture
User offline. Last seen 15 hours 40 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Core Existence: Chain A (max +5000)
Ensures that at least 24% of residues are buried in the core of the entire solution.

Core Existence: Chain B (max +5000)
Ensures that at least 24% of residues are buried in the core of the entire solution.

Core Existence: Total (max +5000)
Ensures that at least 30% of residues are buried in the core of the entire solution.

Residue Count (max +2000 +2200)
Penalizes added residues at a cost of 50 55 pts per residue. Players may add up to 40 residues, for a total of 220.

Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -150 -50 points per atom (not including symmetric copies).

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Joined: 08/11/2010
BluePrint solutions from earlier 1903b

Formula350 offers fixes for Blueprint moving the locked helix bundle (this time it's segments 1 to 52):
https://fold.it/portal/node/2010556#comment-43141

grogar7's picture
User offline. Last seen 11 hours 1 min ago. Offline
Joined: 10/03/2011
residue count filter is misquoted above

I checked and the maximum on the residue count filter is 2200 points. Each additional residue costs 55 points, with a maximum added count of 40 bringing the filter bonus down to 0 points.

bkoep's picture
User offline. Last seen 15 hours 40 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
You're right!

I've amended the Objectives details in the comment above.

Joined: 08/11/2010
while you're at it ...

Buried Unsats only cost -50 each in this puzzle, as it happens. Lucky for me.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons