puzzle picture
1927: Designable Linker Puzzle: Coronavirus Spike Binder
Status: Closed

Groups

RankGroupScorePoints
1Gargleblasters10,279100
2Go Science10,24578
3Void Crushers10,02260
4Contenders10,00845
5Anthropic Dreams9,85633
6Beta Folders9,03724
7L'Alliance Francophone8,77017
8Marvin's bunch8,46112
9Richard Dawkins Foundation8,2548
10BOINC@Poland8,2536
11Needles and Pins7,7474
12SETI.Germany7,6992
13Trinity Biology7,0792
14Team China6,9411
15Fox Folds6,1661
16FoldIt@Netherlands5,7971
17Team Poland5,5201
18MAB_STEM5,3501
19Foldit Staff2,2851
20Rechenkraft.net1,9151
21Combate del coronavirus1,9151


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neilpg628's picture
User offline. Last seen 1 week 4 days ago. Offline
Joined: 08/01/2019
Groups: Foldit Staff
Objectives

Residue Count (max +550)
Penalizes extra residues inserted beyond the starting 240, at a cost of 55 points per residue. Players may use up to 255 residues in total.

Core Existence: LCB1 (max +2400)
Ensures that at least 30 percent of residues are buried in the core of the LCB1-linker unit.

Core Existence: LCB3 (max +2400)
Ensures that at least 30 percent of residues are buried in the core of the LCB3-linker unit.

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Prohibits CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons