I'm wondering if it may not be better to mark DDG, SASA, and SC 'Disabled' again (like it was originally), instead of having even the minuscule bonus, considering the bonus for them ""doesn't work"" as intended? (Provided that CS still isn't fixed by next round)
My thought is --and this is where it's speculation-- that considering the fact that they are not being included in the Undo History, having them disabled again would solve:
-- The "Restore Best" Tools not restoring their respective actual bests. (Thereby alleviating frustration, but also letting Recipes work as intended.)
-- Allow for Evolving to be less confusing for those who aren't aware of what's going on. (To those that don't, you need to disable only your DDG, SASA, SC filters to see the score that everything is working from.)
-- Keep from Undo Points from being overwritten while hand folding, which is caused by various different things... that I unfortunately haven't quite nailed down. ([sorta] Good news is I determined it's a core Foldit issue, not Metrics related; the Auto-Calc method just easily/automatically creates the base scenario to make it easy to encounter.)
Plus, then there's nothing extra to calculate, meaning things can run faster.
Just some food for thought :)
-Form
Buried Unsats (max +500)
Penalizes 60 points for each polar atom that cannot make any hydrogen bonds.
Residue Count (max +275)
Penalizes extra residues inserted beyond the starting 161, at a cost of 55 points per residue. Players may use up to 166 residues in total.
Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.
Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
SS Design (max +500)
Disabled use of CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.
SASA Metric (max +100)
The solvent-accessible surface area that is lost upon binding. The target SASA is 1500 or more.
DDG Metric (max +100)
The predicted binding energy of your design. The target DDG is -40.0 or less.
SC Metric (max +100)
Measures how well your binder fits the contours of the target surface. The target Shape Complementarity is 0.60 or more.