puzzle picture
1918b: Designable Linker: Coronavirus Spike Binder
Status: Closed


1Go Science21,546100
4Anthropic Dreams21,34036
5Void Crushers20,74024
6Beta Folders20,73216
7L'Alliance Francophone20,35910
8Marvin's bunch20,3466
10Hold My Beer19,7052
11Italiani Al Lavoro19,3841
13Team China17,8861
14E?????! Heureka!17,2241
15Foldit Staff13,6631
16Team Canada8,4071

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Joined: 09/29/2016
Groups: Gargleblasters
Objectives - (Copy of bkoep's comment in original 1918 puzzle)

Residue Count (max +550)
Penalizes extra residues inserted beyond the starting 205, at a cost of 55 points per residue. Players may use up to 215 residues in total.

Core Existence (max +2400)
Ensures that at least 28 percent of residues are buried in the core of the monomer unit.

Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Prohibits CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

EDIT: FULL DISCLOSURE - I changed the wording from:
"Penalizes all CYS residues."
... to:
"Prohibits CYS residues."
Reason: We are not allowed to mutate in Cysteine and therefore, by definition, we aren't able to be "Penalized" for using it since we are unable to use it; thus, my swapping of it for "Prohibits".

Joined: 05/19/2009
Groups: Contenders

@bkoep, Why is a member of a competing team posting the objectives where this should be done by an official member of Foldit staff ?
This suggests credibility in an official position where this is not the case.

bkoep's picture
User offline. Last seen 2 days 5 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff

Sorry, Bletchley Park. We've got our hands full and forgot to post the Objectives comment when we reposted this puzzle. I'm guessing that Formula350 simply copied the Objectives details from the original puzzle. In any case, the info seems to be correct.

I appreciate Formula350 helping out, and I don't want to discourage players from commenting with info that others might find useful. I do agree some context might improve clarity here (e.g. adding the phrase "Copied from original puzzle comments..." somewhere with the objective details).

Joined: 09/29/2016
Groups: Gargleblasters
No problem, and will do in the future.

Sorry for the mix-up :)

APPAAP's picture
User offline. Last seen 7 weeks 6 days ago. Offline
Joined: 04/25/2020
Groups: None

Does anyone know why in the one of the two frozen a-helices (the second one according to the segment numbers)there are clashes?

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