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1916b: MERS-CoV Binder Design: Round 4
Status: Closed
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Soloists
1 | Enzyme 51 8 | Gargleblasters | 17,594 | 100 | 2 | ZeroLeak7 23 4 | Go Science | 17,544 | 97 | 3 | nspc 61 32 | Go Science | 17,292 | 94 | 4 | ucad 93 21 | | 17,151 | 90 | 5 | NinjaGreg 25 20 | Go Science | 17,142 | 87 | 6 | grogar7 62 3 | Anthropic Dreams | 17,124 | 84 | 7 | Mike Lewis 9 13 | Gargleblasters | 17,071 | 81 | 8 | ichwilldiesennamen 3 1 | Go Science | 17,061 | 78 | 9 | martinzblavy 35 40 | Contenders | 16,978 | 75 | 10 | fpc 43 24 | Marvin's bunch | 16,962 | 72 | 11 | Skippysk8s 17 25 | Gargleblasters | 16,900 | 69 | 12 | Bruno Kestemont 2 6 | Go Science | 16,898 | 67 | 13 | Blipperman 28 45 | Gargleblasters | 16,882 | 64 | 14 | mirp 1 6 | Go Science | 16,796 | 62 | 15 | fiendish_ghoul 93 19 | | 16,777 | 59 | 16 | justjustin 93 26 | Anthropic Dreams | 16,770 | 57 | 17 | Bletchley Park 11 53 | Contenders | 16,752 | 55 | 18 | ShadowTactics 93 71 | BOINC@Poland | 16,676 | 53 | 19 | dcrwheeler 93 5 | | 16,653 | 50 | 20 | Formula350 22 38 | Gargleblasters | 16,639 | 48 | 21 | silent gene 5 11 | Go Science | 16,616 | 46 | 22 | Czim 7 100 | Go Science | 16,611 | 45 | 23 | NeLikomSheet 93 23 | | 16,608 | 43 | 24 | johnmitch 93 12 | | 16,536 | 41 | 25 | John McLeod 49 22 | Anthropic Dreams | 16,486 | 39 | Need this puzzle? Log in to download.
Comments
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Buried Unsats (max +500)
Penalizes 60 points for each polar atom that cannot make any hydrogen bonds.
Residue Count (max +275)
Penalizes extra residues inserted beyond the starting 161, at a cost of 55 points per residue. Players may use up to 166 residues in total.
Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.
Interaction Energy (max +500)
Monitors that all large PHE, TYR, and TRP residues are scoring well.
Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.
SS Design (max +500)
Disabled use of CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.
SASA Metric (max +1000)
The solvent-accessible surface area that is lost upon binding. The target SASA is 1500 or more.
DDG Metric (max +1000)
The predicted binding energy of your design. The target DDG is -40.0 or less.
SC Metric (max +1000)
Measures how well your binder fits the contours of the target surface. The target Shape Complementarity is 0.60 or more.