1916b: MERS-CoV Binder Design: Round 4
|Name:||1916b: MERS-CoV Binder Design: Round 4|
|Expired:||11/19/2020 - 23:00|
|Description:||Note: This puzzle replaces Puzzle 1916, which revealed a bug in the Contact Surface metric. This puzzle lacks the Contact Surface metric, but players may load solutions from the original Puzzle 1916.
Design a binder for the viral spike of MERS-CoV! This puzzle is similar to the previous round. In this puzzle, the Metrics have a ramped bonus; as you improve DDG, SASA, and SC, you will get an increasing bonus until you reach the threshold of DDG < -40, SASA > 1500, and SC > 0.6, and then the bonus will be capped. Remember that Metrics are slow to compute and run in the background, so gameplay may be different from regular puzzles. See the blog for more info about Foldit Metrics.
MERS is a respiratory disease similar to COVID-19, and is caused by a related coronavirus. There have been several MERS outbreaks since 2012, but there is still no treatment has been developed for the disease. The MERS-CoV virus is coated with a spike protein that recognizes the human protein DPP4, which is found on the surface of lung cells. A protein that binds to the MERS-CoV spike could be used as a drug to block DPP4 recognition and slow viral infection.
In this puzzle, players are presented with the binding site of the MERS-CoV spike protein. The backbone and most of the sidechains are completely frozen, except for flexible sidechains at the binding site, where the spike protein normally interacts with the human receptor protein. Players can design a new protein that binds to these sidechains, blocking interactions with the human receptor. In order to bind the MERS-CoV target, designs will need to make lots of hydrophobic contacts and satisfy any polar atoms that are buried at the interface. But designs will also need to have lots of secondary structure (helices or sheets) and a large core, so that they fold up correctly! See the puzzle comments for Objective details.
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