1915: Designable Linker: Coronavirus Spike Binder
|Name:||1915: Designable Linker: Coronavirus Spike Binder|
|Expired:||11/18/2020 - 23:00|
|Description:||This is the second puzzle in the designable linker series! We are providing parts of two of the best-known designed binders to the SARS-CoV-2 spike, and are challenging players to link them together with a rigid linker! The two helical bundles are the parts of the two binders. They are currently connected with a flexible alanine linker that needs to be redesigned. We have also included the parts of the actual spike that are within 20 angstroms of the termini of the helices on the binders, so you know what regions your binder has to avoid to prevent clashing. The designable helices are a possible starting point for your linker designs.
Currently everything is frozen except for the linker and a portion of the helix on each binder. These residues are designable, and only residues on the linker and helices can be added and deleted. The two binder domains are held in place with strong constraints.
We have included a few objectives to help players generate well-folded designs. There are also some important differences between this and the first designable linker puzzle.
Need this puzzle? Log in to download.