puzzle picture
1907: MERS-CoV Binder Design
Status: Closed

Groups

RankGroupScorePoints
1Gargleblasters14,229100
2Go Science14,08673
3Anthropic Dreams13,98852
4Contenders13,96736
5Beta Folders13,95424
6Hold My Beer13,70416
7L'Alliance Francophone13,37410
8Void Crushers13,2806
9Marvin's bunch12,9744
10BOINC@Poland12,8982
11Russian team12,7641
12SETI.Germany12,5991
13FoldIt@Netherlands11,7821
14Team China11,5591
15Rechenkraft.net10,7111
16Boilermakers5,6891
17MAB_STEM2,9771


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bkoep's picture
User offline. Last seen 18 hours 14 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

DDG Score (max +0)
The predicted binding energy of your design. The target DDG is -40.0 or less.

SASA Score (max +0)
The solvent-accessible surface area that is lost upon binding. The target SASA is 1500 or more.

Shape Complementarity (max +0)
Measures how well your binder fits the contours of the target surface. The target Shape Complementarity is 0.60 or more.

Buried Unsats (max +500)
Penalizes 60 points for each polar atom that cannot make any hydrogen bonds.

Residue Count (max +275)
Penalizes extra residues inserted beyond the starting 161, at a cost of 55 points per residue. Players may use up to 166 residues in total.

Core Existence (max +1500)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Disabled use of CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons