puzzle picture
1904: Coronavirus Binder Design: Round 20
Status: Closed

Groups

RankGroupScorePoints
1Go Science15,142100
2Gargleblasters15,13576
3Anthropic Dreams14,99156
4Beta Folders14,96141
5Contenders14,91829
6Marvin's bunch14,76820
7BOINC@Poland14,70114
8L'Alliance Francophone14,6349
9Void Crushers14,4186
10Russian team14,2724
11Hold My Beer14,1122
12FoldIt@Netherlands13,9331
13SETI.Germany13,5571
14Italiani Al Lavoro10,9941
15MAB_STEM10,6211
16Rechenkraft.net6,6661
17Team Canada01
18practice01
19Window Group01


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bkoep's picture
User offline. Last seen 12 hours 19 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

DDG Score (max +0)
The predicted binding energy of your design. The target DDG is -40.0 or less.

SASA Score (max +0)
The solvent-accessible surface area that is lost upon binding. The target SASA is 1500 or more.

Shape Complementarity (max +0)
Measures how well your binder fits the contours of the target surface. The target Shape Complementarity is 0.60 or more.

Buried Unsats (max +320)
Penalizes 60 points for each polar atom that cannot make any hydrogen bonds. Note that the frozen target includes 3 buried unsats that may be impossible for players to satisfy.

Residue Count (max +275)
Penalizes extra residues inserted beyond the 177, at a cost of 55 points per residue. Players may use up to 182 residues in total.

Core Existence (max +2400)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Disabled use of CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons