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Case number:845799-2010478
Topic:Biochem
Opened by:alcor29
Status:Open
Type:Question
Opened on:Thursday, October 1, 2020 - 17:59
Last modified:Saturday, October 3, 2020 - 18:59

I seem to be able to deal with SASA and SC well enough. Can't figure out however, how to improve DDG. Can you suggest what specifics determine the DDG score, or what are the alternative ways to improve it? Thanks.

(Thu, 10/01/2020 - 17:59  |  2 comments)


agcohn821's picture
User offline. Last seen 9 hours 40 min ago. Offline
Joined: 11/05/2019
Groups: Foldit Staff

Hi Alcor29

Thank you so much for your question--I have passed it along to the team.

bkoep's picture
User offline. Last seen 1 day 10 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff

DDG measures how much the binding interface contributes to your score. DDG should improve (become more negative) with tight packing around hydrophobic residues on the target, and H-bonds to polar atoms on the target.

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