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| Case number: | 845799-2010478 |
| Topic: | Biochem |
| Opened by: | alcor29 |
| Status: | Open |
| Type: | Question |
| Opened on: | Thursday, October 1, 2020 - 17:59 |
| Last modified: | Saturday, October 3, 2020 - 18:59 |
I seem to be able to deal with SASA and SC well enough. Can't figure out however, how to improve DDG. Can you suggest what specifics determine the DDG score, or what are the alternative ways to improve it? Thanks.
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Sat, 10/03/2020 - 18:59
#2
DDG measures how much the binding interface contributes to your score. DDG should improve (become more negative) with tight packing around hydrophobic residues on the target, and H-bonds to polar atoms on the target.
Hi Alcor29
Thank you so much for your question--I have passed it along to the team.