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1889: Coronavirus Anti-inflammatory Design: Round 12
Status: Closed


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bkoep's picture
User offline. Last seen 3 hours 13 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff

Buried Unsats (max +100)
Penalizes 60 points for each polar atom that cannot make any H-bonds. Note that the frozen target includes 15 buried unsats that may be impossible to satisfy.

Residue Count (max +275)
Penalizes extra residues inserted beyond the starting 151, at a cost of 55 points per residue. Players may use up to 156 residues in total.

Core Existence (max +1000)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

bkoep's picture
User offline. Last seen 3 hours 13 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Sandbox puzzle with binder metrics

We've also posted a non-competitive version of this puzzle with binder metric Objectives, as Sandbox Puzzle 1889 with Binder Metrics.

Players may share solutions freely between this puzzle and the sandbox puzzle to check the binder metrics of their Puzzle 1889 solutions.

Joined: 09/24/2012
Groups: Go Science
Great !

It's usefull and relatively easy to use. But it would be VERY usefull if the metrics would be awarded a (numerical) 0.000001 x metrics bonus.

With this small bonus correlated with the metrics, we could create different scripts in order to optimize our solutions (from the scientist's point of view) without influencing the competition score.

I hope that this is possible without compromizing the loading back into the competition puzzle (because still many of us are more competing than purely working for science).

Joined: 08/11/2010
Congratulations: $3M Breakthrough Prize to Dr Baker
spvincent's picture
User offline. Last seen 43 min 48 sec ago. Offline
Joined: 12/07/2007
Groups: Contenders
Yesterday I ran a script to

Yesterday I ran a script to try and evo a teammates solution which had a score of 11583. The script crashed after a bit apparently without registering any gain and I then logged off.

This morning, to my surprise, I see I'm registered on the website as having evod with a score of 11763. Looking at my local Evolver solutions, it seems the Recent Best and Very Best solutions remain at 11583, and yet there is a Quicksave Evolver Solution 23 with a score of 11680. When I try to load this last solution however (and after running Filters) it gives a score of 11440 and says I've evo'd.

All rather confusing. I've scientist-shared The Quicksave solution.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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