puzzle picture
LCB1 Coronavirus Spike Binder (corrected)
Status: Closed

Summary

Name: LCB1 Coronavirus Spike Binder (corrected)
Status: Closed
Created: 08/31/2020
Points: 0
Expired: 09/30/2020 - 23:00
Difficulty: Novice
Description: Note: This replaces the original LCB1 puzzle, which had some incorrect settings for Core Exists, Ideal Loops, and SS Design Objectives.

This is a non-competitive "sandbox" puzzle where you can explore a protein designed by IPD scientists. The starting structure is LCB1, a designed protein that binds to the coronavirus spike protein to block viral infection. This design was just one of millions of proteins designed by researchers. It was chosen for testing because it has excellent binder metrics. Lab tests have shown that this binder can potently inhibit viral infection in a test tube, but further tests are needed to determine safety and efficacy in animals.

Read more about this protein on the Foldit blog.
Categories:

Top Groups

RankGroupScorePoints
1Go Science13,9920
2Gargleblasters13,9680
3Anthropic Dreams13,6910
4Biochem-AD1713,4660
5foldeRNA13,4290

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Comments

Joined: 09/24/2012
Groups: Go Science
Solution from old puzzle appear

But it has diffrent length and cannot be imported (it's no proble for playing this puzzle), just fyi)

bkoep's picture
User offline. Last seen 3 hours 44 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Apologies

Yes, sorry! Originally we wanted to allow players to load solutions from Puzzle 1880, but there were some problems.

Joined: 05/19/2009
Groups: Contenders
I am surprised score-wise

I am surprised that there is so much headroom (points-wise) for this structure if the given structure binds so well with the target ?

bkoep's picture
User offline. Last seen 3 hours 44 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Refinement

Yes, IPD scientists tend to spend much less time refining their designs.

This is an ongoing concern in Foldit. Lots of Foldit players seem to do a lot of late-game refinement of their solutions, because it improves their competitive advantage. But it is not clear that all this refinement actually improves the scientific value of the model.

Joined: 03/28/2020
Groups: Go Science
Buns Objective

This design has an ugly bunch of BUNs all over the structure. What is the point of us in taking care of getting rid of BUNs if this design is so great? Aren't BUNs that important?

bkoep's picture
User offline. Last seen 3 hours 44 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Yes!

The BUNS Objective in Foldit uses some approximations to speed up calculations, so it will sometimes produce false positives.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons