puzzle picture
1883: Coronavirus Anti-inflammatory Design: Round 11
Status: Closed

Soloists

RankPlayerGroupScorePoints
101Mohoernchen 70 292  9,1681
102Dr.Sillem 70 79  9,1171
103deathbat_87 70 591  9,1071
104em.c123 70 1873  9,0181
105kludbrook 70 860  9,0111
106Bucsan 70 806  8,9871
107jacob_n 70 406  8,9481
108rinze 70 84  8,8421
109rabamino12358 70 628  8,7571
110abstract45 70 1873  8,5851
111scoobydooboo 70 1873  8,5841
112versat82 70 860 Rechenkraft.net8,5821
113dahast.de 70 206  8,5161
114Raguth Wolf 70 1873  8,4801
115rezaefar 70 103  8,4101
11615matt95 70 1873  8,3611
117Swapper242 70 148 Go Science8,3561
118hajtogato 70 465  8,3181
119manasa 70 806 Go Science8,2841
120400134401 70 1873 8,2641
121pfirth 70 378  8,0861
122heyubob 70 1873 Gargleblasters8,0611
123Bearpaw 70 1873 Team Canada8,0311
124fsk8r 70 953  7,9781
125cobaltteal 70 1873  7,9451


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bkoep's picture
User offline. Last seen 1 day 8 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Buried Unsats (max +100)
Penalizes 60 points for each polar atom that cannot make any H-bonds. Note that the frozen target includes 15 buried unsats that may be impossible to satisfy.

Residue Count (max +275)
Penalizes extra residues inserted beyond the starting 151, at a cost of 55 points per residue. Players may use up to 156 residues in total.

Core Existence (max +1000)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Norrjane's picture
User offline. Last seen 1 week 3 days ago. Offline
Joined: 09/27/2014
Groups: Go Science
Bradykinin vs Cytokine Storm

There is some new research suggesting that it may be a bradykinin vs cytokine storm. Would that change the dynamics of these anti-inflammatory Design puzzles?

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons