puzzle picture
1883: Coronavirus Anti-inflammatory Design: Round 11
Status: Closed

Groups

RankGroupScorePoints
1Anthropic Dreams12,030100
2Gargleblasters11,92873
3Marvin's bunch11,74852
4Go Science11,73036
5Contenders11,72624
6Beta Folders11,56016
7Void Crushers11,54310
8Russian team11,3956
9BOINC@Poland11,3544
10L'Alliance Francophone11,1672
11Hold My Beer10,4701
12Rechenkraft.net8,5821
13BIOCHEM 3Z03 Winter 20208,2641
14Team Canada8,0311
15SETI.Germany7,2221
16Foldit Staff2,2501
17FoldIt@Netherlands01


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bkoep's picture
User offline. Last seen 11 hours 43 sec ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Buried Unsats (max +100)
Penalizes 60 points for each polar atom that cannot make any H-bonds. Note that the frozen target includes 15 buried unsats that may be impossible to satisfy.

Residue Count (max +275)
Penalizes extra residues inserted beyond the starting 151, at a cost of 55 points per residue. Players may use up to 156 residues in total.

Core Existence (max +1000)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Norrjane's picture
User offline. Last seen 1 week 1 day ago. Offline
Joined: 09/27/2014
Groups: Go Science
Bradykinin vs Cytokine Storm

There is some new research suggesting that it may be a bradykinin vs cytokine storm. Would that change the dynamics of these anti-inflammatory Design puzzles?

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons