puzzle picture
1877: Coronavirus Anti-inflammatory Design: Round 10
Status: Closed

Groups

RankGroupScorePoints
1Go Science11,894100
2Contenders11,87778
3Gargleblasters11,86060
4Anthropic Dreams11,82345
5L'Alliance Francophone11,63533
6Beta Folders11,46824
7Void Crushers11,42617
8Marvin's bunch11,41012
9BOINC@Poland11,2748
10Hold My Beer10,6456
11Russian team10,6264
12Team South Africa9,4712
13Team Poland9,0602
14Team Canada8,4781
15Rechenkraft.net8,2941
16SETI.Germany7,7771
17Boilermakers5,5151
18Italiani Al Lavoro4,2901
19MTS - Proteins 3,1771
20Team China01
21Macromolecules@MQ 202001


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bkoep's picture
User offline. Last seen 3 hours 16 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Buried Unsats (max +100)
Penalizes 60 points for each polar atom that cannot make any H-bonds. Note that the frozen target includes 15 buried unsats that may be impossible to satisfy.

Residue Count (max +275)
Penalizes extra residues inserted beyond the starting 151, at a cost of 55 points per residue. Players may use up to 156 residues in total.

Core Existence (max +1000)
Ensures that at least 25 percent of residues are buried in the core of the monomer unit.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

bkoep's picture
User offline. Last seen 3 hours 16 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Binder metrics devprev puzzle

Devprev users should try the devprev version of this puzzle, with new objectives for DDG, SASA, and SC binder metrics. Players may share solutions freely between this puzzle and devprev version.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons