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Newsletter June 25: We've Been Busy!

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 2005: IL-2R Binder Design

Puzzle 2006: Symmetric D2 Tetramer Design: Limited Interface

Puzzle 2007: Large Electron Density Transcription factor

Upcoming Updates

Here’s what the devs have been up to lately:

  • New interns! Our team has two new interns from RosettaCommons, Foldit’s larger software development community. (Rosetta is the software Foldit is built on!) Our interns will be working on special new levels and contests, major server improvements to Dojo mode, and a bunch of new levels, tweaks, and updates to Dojo mode.
  • The great mergening! We’re doing some big changes on our backend to update Foldit with some of the latest and greatest tools from Rosetta. Not only does this mean our development process will get a much-needed tune-up, we’ll also have some new tools available to work with. If you’ve been following the news on trRosetta, or if you like the idea of adding deep neural networks to your folding, this is the part where you squeal with delight.
  • Better help. We’re polishing the in-game help panel (which has seen improvements since this wiki page was updated) to be even more flexible and helpful.
  • Bringing back the R. We’re really sorry that the R hotkey for removing bands was taken over by the Remote Control feature. We’re bringing back your hotkeys, for real this time.
  • A whole new perspective! Soon you’ll be able to check your fold in an orthographic view! Thanks jeff101 for the suggestion!

Wow, that’s a ton! Bear with us while we try to roll out all of these cool new improvements. It might take us a while to get them all tested and ready to go.

Today’s Master Folding Tips

Do you have trouble with getting the hydrogen bonds right on your sheets? Here’s some diagrams and explanations on the geometry of sheet bonding.

There’s a lot you can learn from your fellow players. Join a group and share your solutions! Both the sharer and the evolver tend to learn something from the process.

Until next time, happy folding!

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Newsletter July 2: Another Year, Another Newsletter

Hey folders!

Dev Josh here with your weekly Foldit update. Can you believe I’ve been writing these newsletters for an entire year now? The first newsletter was July 3, 2020, before binding metrics were even added to the game! What a long, strange trip it’s been.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 2008: TGF Receptor Binder Design

Puzzle 2009: Symmetric D2 Tetramer Design: H-bond Networks

Puzzle 2010: Bos Taurus

Recipe of the Week

For the veteran folders out there, LociOiling has added a bugfix to Bruno Kestemont’s Banded Worm Pairs (BWP) in versions 3.4.8 and 1.4.9.

Player of the Week

A huge congratulations and thanks to NinjaGreg! Not only has his design of the month been synthesized in the wet lab, but he has also been volunteering with the Foldit dev team to help us fix bugs and add new features! You rock, Greg.

Today’s Master Folding Tips

Given the new updates to Banded Worm Pairs (BWP), let’s break down what exactly this recipe is doing and how to use it. This is a very late game recipe for squeezing out just a couple of extra points at the very end of a puzzle. The original BWP was actually written by KarenCH and based on an even older “worm” wiggle by rav3n_pl. Since then, a number of worm recipes have spawned based on this approach. They’re crawling all over the place!

BWP uses bands and local wiggling to try to optimize your fold. The recipe usage itself is pretty simple. The slider adjusts how often you want to save progress, ranging from every time you gain 0.3 points to 1000 points from the recipe. And the textbox is for a name for the save file. These saves are stored in the Menu under Open/Share Solutions. In the later versions of this recipe, it also accounts for objectives like H-Bond Networks, and will run infinitely until you tell it to stop.

Want us to keep talking about recipes, or something else? Post your feedback on our feedback forum!

Until next time, happy folding!

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Newsletter July 9: It's Atomic!

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 2011: Cortisol Ligand Binder Design

Puzzle 2012: Symmetric D2 Tetramer Design: H-bond Networks

Puzzle 2013: Scorpion Toxin

Player of the Week

Did you know that every week, LociOiling collects even more screenshots from the top puzzle results and posts them to the Foldit Wiki? What a champ, thanks Loci! Be sure to check out those results so you can see what the top folders are doing in every puzzle!

Today’s Master Folding Tips

Even though Foldit colors entire sidechains as hydrophobic or hydrophilic, this is actually a property of the individual atoms that make up a sidechain! Carbons are hydrophobic, while polar atoms like oxygen and nitrogen are hydrophilic. Keep this in mind when packing your interfaces and cores: it’s not just what sidechains you use, but how you angle them! Hydrophobicity is atomic!

We’re making some major improvements to Dojo mode! Be sure to check it out and let us know what you think on the forums or the #dojo channel of our Discord server!

Until next time, happy folding!

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Newsletter July 16: The Art of a Good Wiggle

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 2014: TGF Receptor Binder Design

Puzzle 2015: Symmetric D2 Tetramer Design: H-bond Networks

Puzzle 2016: Nucleosome Protein

Recipe of the Week

Wiggle Shake Wiggle by SaveVMK and Pikamander2

Art of the Week

This week’s art comes from Nicm25! Who knew bands could be such a great artistic tool?

Today’s Master Folding Tips

Moving stuff around in Foldit can be hard. That’s why I made this guide to learn about controlling your movements in 3D space!

Do you have a recipe or screenshot to share? Send it in to mail.fold.it@gmail.com!

Until next time, happy folding!

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Newsletter 7/23/21: So Exciting, I Can’t Talk About It

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 2017: IL-2R Binder Design

Puzzle 2018: Symmetric D2 Tetramer Design: H-bond Networks

Puzzle 2019: Crystallin

Upcoming Updates

We’ve got some seriously exciting new things happening just around the corner! But I will let bkoep talk about it more in the next lab report. Instead, I’ll simply share some cool new scientific papers we’ve all got our eyes on:

The Baker Lab at UW has developed a protein prediction algorithm called RoseTTAFold in their latest paper Accurate prediction of protein structures and interactions using a three-track neural network. Meanwhile, literally published on the same day, DeepMind finally describes their own algorithm, AlphaFold, in their article Highly accurate protein structure prediction with AlphaFold. Could this mean we have brand new technologies for quickly identifying whether a fold will be successful? Only time will tell!

Art of the Week

The Olympic, by Nicm25

Today’s Master Folding Tips

Do you tend to cut your protein apart at the loops, but then you can’t get your loops ideal when you merge them back together? Try cutting in the middle of your sheets and helices instead! This preserves your loops better and makes it easier to idealize loops after merging.

Make sure you subscribe to our YouTube channel and click that bell icon so you get notified when our lab reports go live! You won’t want to miss this!

Until next time, happy folding!

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons