Foldit Newsletter July 17: Bonjour Encore Triple Hélice
Dev Josh here with your weekly Foldit update.
3 Solutions from This Week's Puzzle
(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)
Puzzle 1861: Symmetric Trimer Design: Buried Unsats
This solution took a less common approach to the triple helix meta. I'll let you decide for yourself whether you think it scored well or not. What do you think of it? Let us know in the Discord!
Puzzle 1862: Coronavirus Round 13
An extra special congratulations goes to clark92 for being top rank for this puzzle! This up-and-coming folder only started folding at the end of February, and already they've taken the leaderboards by storm!
These solutions come from some of our beginner folders! Can you tell what they could do better?
As a reminder, here are some helpful tips from bkoep on designing a good binder!
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Recipe of the Week
Player of the Week
If you're still on the intro puzzles, nspc also has a video on beating Hydrophobic Disaster.
I think I speak for everyone when I say merci beaucoup! Nspc (pc on Discord) is a beginner folder who has been learning fast by being really active in the chat. Say hi next time you see them around!
Art of the Week
Here's some art from 1861: a cool-looking triangle and a crazy ball of... I don't even know what... Thanks for sharing!
Today’s Master Folding Tips
Despite how common they are, I really recommend trying a helix bundle like the ones you've seen from the top-scoring solutions! Helices are easier to make than loops or sheets, so practicing on helix bundles is a great way to get a higher rank and practice the basics before trying something tricky and advanced like long loops or a sheet structure.
Are you paying attention to which structures your AA structure preferences. AAs prefer to be in? It's not a hard-and-fast rule, but check out the wiki for AA structure preferences. I find this especially helpful for getting started by mutating my isoleucines away into something more suitable for the structure I'm designing, like asparagines for loops, valines for sheets, and MALEK for helices.
How many structural motifs can you name? Most of you know pi stacking, some of you even know about beta hairpins. But do you know about ST turns, Greek keys, and Omega loops? What about sequence motifs?
Having these concepts in your toolkit will give you more conceptual legos from natural proteins to think about when designing. There's plenty of research out there on common patterns, and if you're looking for expert tips, then you're ready to dig into real literature. Good luck, and let us know what you find on the
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Until next time! Happy folding!( Posted by agcohn821 68 927 | Fri, 07/24/2020 - 03:47 | 0 comments )