puzzle picture
1864: Symmetric Trimer Design: Limited Interface
Status: Closed

Summary

Name: 1864: Symmetric Trimer Design: Limited Interface
Status: Closed
Created: 07/15/2020
Points: 100
Expired: 07/22/2020 - 23:00
Difficulty: Intermediate
Description: Design a symmetric protein trimer, with 3 identical chains that assemble together! This puzzle has no H-Bond Network objective, but there is "Core Limit: Complex" objective meant to limit the size of the interface between symmetric chains. An interface that is too large, with too many orange hydrophobics, can prevent the individual subunits from folding properly. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Categories: Design, Overall, Symmetry

Top Groups

RankGroupScorePoints
1Go Science19,049100
2Anthropic Dreams18,82473
3Gargleblasters18,65452
4Void Crushers18,56536
5Beta Folders18,56324

Top Evolvers

Top Soloists



Need this puzzle? Log in to download.  

Comments

bkoep's picture
User offline. Last seen 4 hours 18 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Buried Unsats (max +500)
Penalizes polar atoms that cannot make hydrogen bonds, -150 points per atom (not including symmetric copies).

Core Existence: Monomer (max +2000)
Ensures that at least 20 residues are buried in the core of the monomer unit.

Core Limit: Complex (max +500)
Checks that no more than 72 residues are buried in the symmetric complex, including the interface between monomer units.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

HuubR's picture
User is online Online
Joined: 04/13/2020
Groups: Gargleblasters
Complex core: (no?) limits

The last sentence of the Description ("no limits on the Complex Core", "H-bond Networks") confuses me. It seems to contradict the first part of the description: "no H-Bond Network objective, but there is "Core Limit: Complex" objective".

Was the last sentence unintentionally copied from the previous Symmetry puzzles, or am I missing the point here?

Joined: 11/05/2019
Groups: Foldit Staff
Question

Hi HuubR--I have passed your question along to the team. Thank you!

bkoep's picture
User offline. Last seen 4 hours 18 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Good catch!

The last sentence was a mistake that was shamelessly copied from previous puzzles. I've updated the puzzle description.

Download links:
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.12 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Other Games: Mozak
Search
Only search fold.it
Recommend Foldit
User login
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons