Newsletter July 10: Triple-Quad Helices and Borromean Rings

(This post was originally sent out on July 10 to our mailing list. You can sign up for the mailing list here to receive weekly updates about Foldit, including tips and tricks and see the top-scoring solutions to the week's puzzles. Don't forget to join our Discord as well to stay in the chat even when you're not folding!)

Hey folders!

Dev Josh here with your weekly Foldit update.

Solutions from This Week's Puzzles

(Disclaimer: This is not scientific feedback; these solutions are not officially endorsed by the Foldit scientists.)

Puzzle 1858: Symmetric Trimer Design

Personally, I went with a 4-helix design for this puzzle, and it seems like that's what a lot of the highest scoring solutions did. But there were also a couple of 3-helix designs, and even some sheets!

Puzzle 1860: Refinement R1040

The highest scoring solutions for this puzzle kept two medium-sized sheets lined up and folded the rest into short helices around a core.

Compare this to some of the intermediate solutions. Although these folds are okay, they had some minor problems: some loose helices and poor scoring ends.

What was the trickiest part for you about this puzzle? Let's talk about it in Discord!

Recipe of the Week

This week's recipe has been described by Phyx as "The Best Recipe of 2014": Wisky's Repeating Rebuild All!

Let this late-game recipe run for 3-4 hours and it will do some rebuilding magic on your pose.

Player of the Week

I want to honor LociOiling! for constantly being the #1 contributor to our wiki!. This week he created the pages for Reaction Design Puzzles and Camera Controls! If you've ever read a wiki page that was made in the last few years, chances are Loci wrote it. Give him your thanks in chat next time you use the wiki!

Art of the Week

This week's most beautiful fold comes from Formula350 for his Borromean rings! This would never fold up in real life, but wow, is it pretty!

Today’s Master Folding Tips

Beginner: Don't be afraid to reassign your secondary structures to different sheets and helices! While this might seem like you're "changing the puzzle," you're really just making a suggestion for what shape the protein should take, and this suggestion can help your other tools better serve you. Try a bunch of different secondary structure assignments and use Ideal SS on them afterward, then see how this new arrangement might be easier or harder to fold. Play around with it, Foldit is about experimenting!

Intermediate: If you haven't learned to use Backbone Pins yet, I highly recommend it. This tool, hidden away in the view options, gives you more control over wiggling than CI alone. A locked pin is similar to a ZLB, it will keep your wiggle locked to that spot, while moving everything else more.

Expert: Although it might seem like more hbonds means better binding, hbonds at the interface don't actually add to the strength of the bind, since they aren't much stronger than these atoms simply binding to water. What use are interface hbonds then? Their purpose is eliminating BUNS. The real strength of your binding comes from hydrophobic interactions, shown in the Hiding and Packing subscores, and your hbond network gives the bind its specificity.

Want to recommend a recipe of the week or have your solution featured in the next newsletter? Send us your cookbooks and screenshots, we'd love to see what you're up to!

Until next time, happy folding!

( Posted by  joshmiller 68 563  |  Tue, 07/14/2020 - 20:19  |  0 comments )
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons