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1858: Symmetric Trimer Design: Buried Unsats
Status: Closed

Summary

Name: 1858: Symmetric Trimer Design: Buried Unsats
Status: Closed
Created: 07/01/2020
Points: 100
Expired: 07/08/2020 - 23:00
Difficulty: Intermediate
Description: Design a symmetric protein trimer, with 3 identical chains that assemble together! This puzzle uses the Buried Unsats Objective, which penalizes buried polar atoms that can't make H-bonds. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Categories: Design, Overall, Symmetry

Top Groups

RankGroupScorePoints
1Go Science21,250100
2Anthropic Dreams21,19774
3Contenders20,66654
4Void Crushers20,48438
5Gargleblasters20,29427

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Comments

bkoep's picture
User offline. Last seen 4 hours 51 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Buried Unsats (max +300)
Penalizes polar atoms that cannot make hydrogen bonds, -60 points per atom (not including symmetric copies).

Core Existence: Monomer (max +2200)
Ensures that at least 22 residues are buried in the core of the monomer unit.

Core: Complex (max +0)
Awards no bonuses or penalties. Click Show to see which residues count as "Core" for the H-bond Network objective.

H-bond Network (max +1800)
Rewards networks that comprise at least 3 H-bonds involving core residues.
Between 1 and 9 H-bonds should cross the interface between symmetric units.
Networks must be at least 75% satisfied (i.e. 75% of all bondable atoms in a network must make a H-bond).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

grogar7's picture
User offline. Last seen 1 hour 57 min ago. Offline
Joined: 10/03/2011
definite bug here

Puzzle 1858 and Foldit website are giving me credit for 21152 points on this puzzle, when that is a score with BUNS Filter turned OFF. Best credit score is actually 21086!

Joined: 05/19/2009
Groups: Contenders
Big thank you for reporting this

Thank you grogar7 for reporting it ! This means that this client should be invalidated for new puzzles to prevent players from abusing this scoring loophole.

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