1855: Y1 Receptor ligand design
|Name:||1855: Y1 Receptor ligand design|
|Expired:||07/01/2020 - 23:00|
|Description:||Use the new reaction design tool (blog post) to build a ligand which will bind well to the Y1 Receptor.
We've started you off with an arginine sidechain known to bind in the Y1 pocket. You can use the reaction design tool to grow this molecule to better fill the pocket. The molecules we're interested in at the moment are based on a central arginine core with "decorations" on either side. The reaction design tool will allow you to pick the best combination.
Since the precise 3D structure of the ligand is important, some of the reagent choices are very similar, except for the details of how the atoms are arranged (specifically, their chirality).
For more information about the Y1 receptor, see the previous puzzles: 1441, 1446, 1503 and 1653
|Categories:||Small Molecule Design|
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