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Beginner Puzzle (<150): Coronavirus
Status: Closed

Summary

Name: Beginner Puzzle (<150): Coronavirus
Status: Closed
Created: 06/09/2020
Points: 100
Expired: 07/21/2020 - 23:00
Difficulty: Beginner
Description: Design a protein binder against coronavirus! The starting structure shows how the coronavirus spike protein binds to a human receptor protein. The coronavirus protein (in gray) is mostly frozen, except for the orange and blue sidechains at the binding site. The binding site of coronavirus sticks to the human protein (in color), and this allows the coronavirus to infect human cells. We want to design a new protein that can bind to coronavirus more tightly than the human protein! A tight binder could block the normal coronavirus-human interaction, and might be used as an antiviral drug against coronavirus! Refold and mutate the starting structure to increase your score and improve binding against coronavirus!

START HERE:

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864
_____________________________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :
- try all puzzles not only "Beginners" ones,
- fold first the ones you like the most,
- try it by yourself to understand what works and what doesn't,
- ask for tips in global chat when you think you don't understand something.

Categories: Beginner

Top Groups

RankGroupScorePoints
1Gargleblasters13,712100
2Hold My Beer13,42789
3Go Science13,40979
4Chem Eng Thermo13,18970
5Russian team13,15861

Top Soloists

RankPlayerGroupScorePoints
1OWM3 14 13 Gargleblasters13,712100
2Jakki 102 73  13,619100
3BNet 102 106  13,61399
4SuperEnzyme 102 272  13,56598
5gian667 102 143  13,54098


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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons