Why do the COVID-19 binder design puzzles have us designing a binding protein entirely from scratch? We know what protein binds there in nature. Why not start with that as a base for the docking side, and then modify the other parts of the protein to change what it does once it is bound? Would it not be faster that way to find a good design if we already have a functional design for the docking?
If it is because we do not know how the naturally occurring proteins fold, why not use their design as a starting point, and then try to refine the folding with electron density puzzles?