Foldit Lab Report #8: Check the Fridge

The COVID-19 lockdown continues -- but we have new updates and new puzzles anyway. Watch our latest lab report for more!

NEWS:
• Coronavirus binder testing has been delayed (0:25)

PUZZLE UPDATES:
• Aflatoxin enzymes need re-looping (1:01)
• Coronavirus protein prediction -- can you fold them all? (1:56)
• Coronavirus spike binders -- optimize 'em (2:45)
• Can protein design create a COVID-19 treatment? (3:32)
-- Controlling the cytokine storm: https://youtu.be/S63mysyN910

LAB UPDATES:
• Always check the fridge, because it might contain CRYSTALS (3:57)

DESIGN OF THE MONTH:
• Player Bruno Kestemont created a promising anti-inflamatory protein (5:06)

(Fri, 05/01/2020 - 14:30  |  7 comments)
Joined: 03/30/2013
Groups: Go Science
Surprise crystals

I love surprise crystals. Is that the real diffraction in the video? It looks like it diffracts to very nice resolution. What are the plans for publishing and depositing the structure.

bkoep's picture
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Joined: 11/15/2012
Groups: Foldit Staff
6WI5

No, unfortunately that is not the diffraction for this protein (sorry!). That footage comes from an educational video by The Royal Institution: https://youtu.be/gLsC4wlrR2A

In fact, our test tube crystals did not diffract that well, but we were able to optimize the conditions and get diffraction to 1.83 Å.

The structure has already been deposited in the PDB here!

stomjoh's picture
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Congrats!

WTG fiendish_ghoul and Bruno!

Joined: 04/25/2020
Groups: Go Science
design sharing

How do you share/submit a design you believe is viable?

Joined: 05/09/2008
Groups: None
Here you go!
agcohn821's picture
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Joined: 11/05/2019
Groups: Foldit Staff
Question

Hi SurferSleuth--I have passed your question on to the team! Thank you!

Joined: 03/19/2020
Groups: None
So no tests of protein design of fold.it ?

Man its really sux, that you unable to test all those protein designs,fold.it when you thing to release new statement about testing fold.it stuff ?

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