puzzle picture
1829: Aflatoxin Challenge: Round 16 Loop Prediction
Status: Closed

Summary

Name: 1829: Aflatoxin Challenge: Round 16 Loop Prediction
Status: Closed
Created: 04/23/2020
Points: 100
Expired: 04/30/2020 - 23:00
Difficulty: Novice
Description: Refold the loops in this Aflatoxin Challenge design! This is a followup to Round 14, this time starting with a completely unfolded loop. Previously, Foldit players had redesigned the binding loops of an oxidation enzyme, and testing at the Siegel Lab found that some designs had high oxidative activity for other molecules--but no activity against aflatoxin! We think the redesigned loops might be misfolding when aflatoxin is not in the binding pocket. Misfolded loops could prevent the enzyme from binding aflatoxin and catalyzing the oxidation reaction. We wonder if Foldit players can predict how these binding loops might misfold, by refolding the loops in ways that score better than the original design. If we can figure out how the binding loops misfold, then we might be able to fix them and recover activity against aflatoxin!

Aflatoxins are a class of poisonous compounds that contaminate a significant portion of the global food supply. In the most recent phase of Foldit's Aflatoxin Challenge, the Siegel Lab at UC Davis proposed a new strategy for degrading aflatoxin, asking Foldit players to help redesign an oxidation enzyme so that it could break down aflatoxin molecules. In this puzzle, players can refold the two binding loops of the redesigned enzyme. The rest of the protein is frozen, except for some sidechains that might interact with the binding loops. No mutations or insertions are allowed. Since we are interested in how the protein might fold without aflatoxin, there is no aflatoxin molecule in the binding pocket.

This is the 16th round of our Aflatoxin Challenge, sponsored by Mars Inc. and Thermo Fisher Scientific. Promising designs will be tested by the Siegel Lab at UC Davis. By participating in the challenge/game, the players agree that all player designs will be available permanently in the public domain, and the players will not seek intellectual property protection over the designs created as part of the challenge/game.
Categories: Overall, Prediction

Top Groups

RankGroupScorePoints
1Go Science10,160100
2Contenders10,12282
3Anthropic Dreams10,10166
4Gargleblasters10,02653
5L'Alliance Francophone10,02242

Top Evolvers

RankPlayerGroupScorePoints
1ZeroLeak7 45 13 Go Science10,160100
2Xartos 20 14 Go Science10,15999
3Dhalion 5 71 Go Science10,15998
4mirp 1 1 Go Science10,15996
5Czim 6 72 Go Science10,15995

Top Soloists

RankPlayerGroupScorePoints
1ZeroLeak7 45 13 Go Science10,160100
2BootsMcGraw 38 16 Contenders10,11899
3mirp 1 1 Go Science10,09298
4drumpeter18yrs9yrs 117 74  10,08496
5Xartos 20 14 Go Science10,06795


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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons