bkoep's picture
User offline. Last seen 18 hours 48 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Residue Count (max +440)
Penalizes extra residues inserted beyond the 196, at a cost of 55 points per residue. Players may use up to 204 residues in total.

Interaction Energy (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence (max +2400)
Ensures that at least 28 percent of residues are buried in the core of the monomer unit.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

spvincent's picture
User offline. Last seen 18 min 39 sec ago. Offline
Joined: 12/07/2007
Groups: Contenders
You state that the loops

You state that the loops connecting the helices need redesigning and yet they satisfy the Ideal Loops filter. What other criteria are we supposed to use?

bkoep's picture
User offline. Last seen 18 hours 48 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Backbone subscore

Great question! The problem with these loops is very subtle, and it will probably be important to pay attention to the "Backbone" subscore for these residues (to see residue subscores, mouse-over a residue and press the TAB key).

The test that flagged these loops is much more sensitive (it looks at finer per-atom RMSD) than the Ideal Loop Objective (which looks at coarser ABEGO bins). So, although the backbone torsions fall within the correct ABEGO bins, they may still be outside the most common distribution of torsion values.

jeff101's picture
User offline. Last seen 20 hours 13 min ago. Offline
Joined: 04/20/2012
Groups: Go Science
Solutions from previous rounds

In this puzzle, can we start from our
own solutions from previous rounds?
If so, which rounds' solutions are
allowed here?

bkoep's picture
User offline. Last seen 18 hours 48 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
No loading

No, players may not load solutions from previous puzzles.

Joined: 04/02/2020
Groups: None
Binder puzzle series

Since I´ve seen a lot of players improve in comparison to early rounds of this puzzle I am curious if there will be any additional selections for lab testing? Or is there an updated video discussion on some designs planned? I´d like to see that again.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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