puzzle picture
1825: Coronavirus Binder Design: Round 7
Status: Closed

Groups

RankGroupScorePoints
1Anthropic Dreams16,343100
2Beta Folders16,30484
3Go Science16,28370
4Gargleblasters16,27558
5L'Alliance Francophone16,21848
6Contenders16,17639
7Team India16,12432
8Void Crushers16,10026
9Marvin's bunch16,08820
10FoldIt@Netherlands15,82316
11Russian team15,78613
12BOINC@Poland15,76410
13foldeRNA15,7647
14Hold My Beer15,7586
15Herobrine's Army15,6014
16SOU Biochemistry CH455 (2020)15,5753
17Penny-Arcade15,5252
18SETI.Germany15,4572
19Team South Africa15,4241
20Rechenkraft.net15,3581
21CHNO Junkies15,3241
22Trinity Biology15,2981
23Italiani Al Lavoro15,2821
24Dr. B Orgo 215,2521
25NMHU Biol4230 Spr 2015,2511


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Comments

bkoep's picture
User offline. Last seen 18 hours 27 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Residue Count (max +440)
Penalizes extra residues inserted beyond the 196, at a cost of 55 points per residue. Players may use up to 204 residues in total.

Interaction Energy (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence (max +2400)
Ensures that at least 28 percent of residues are buried in the core of the monomer unit.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

Joined: 12/07/2007
Groups: Contenders
You state that the loops

You state that the loops connecting the helices need redesigning and yet they satisfy the Ideal Loops filter. What other criteria are we supposed to use?

bkoep's picture
User offline. Last seen 18 hours 27 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Backbone subscore

Great question! The problem with these loops is very subtle, and it will probably be important to pay attention to the "Backbone" subscore for these residues (to see residue subscores, mouse-over a residue and press the TAB key).

The test that flagged these loops is much more sensitive (it looks at finer per-atom RMSD) than the Ideal Loop Objective (which looks at coarser ABEGO bins). So, although the backbone torsions fall within the correct ABEGO bins, they may still be outside the most common distribution of torsion values.

jeff101's picture
User offline. Last seen 19 hours 53 min ago. Offline
Joined: 04/20/2012
Groups: Go Science
Solutions from previous rounds

In this puzzle, can we start from our
own solutions from previous rounds?
If so, which rounds' solutions are
allowed here?

bkoep's picture
User offline. Last seen 18 hours 27 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
No loading

No, players may not load solutions from previous puzzles.

Joined: 04/02/2020
Groups: None
Binder puzzle series

Since I´ve seen a lot of players improve in comparison to early rounds of this puzzle I am curious if there will be any additional selections for lab testing? Or is there an updated video discussion on some designs planned? I´d like to see that again.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons