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1818: Coronavirus Binder Design: Round 5
Status: Closed

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bkoep's picture
User offline. Last seen 52 min 33 sec ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Residue Count (max +550)
Penalizes extra residues inserted beyond the starting 192, at a cost of 55 points per residue. Players may use up to 202 residues in total.

Interaction Energy (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence (max +2400)
Ensures that at least 28 percent of residues are buried in the core of the monomer unit.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA in helices.

Joined: 09/24/2012
Groups: Go Science
do you expect

that we try to keep the structure of the face binding to the virus ? (then bot mutating the binding without burials of the helices). ?

bkoep's picture
User offline. Last seen 52 min 33 sec ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Up to you!

We think the starting interface looks pretty good, so it might be okay to keep the binding face the same and focus on refolding the sheets.

However, if you think you can improve the binding interface, go for it!

Joined: 03/30/2020
Groups: None
hüpfen

ich finde es ist nicht nur ein Spiel es hilft auch den Wissenschaftlern,rinenn das corona Virus zu bremsen.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons