puzzle picture
Protein Design Sandbox
Status: Active

Summary

Name: Protein Design Sandbox
Status: Active
Created: 03/22/2020
Points: 0
Expires: 03/29/2025 - 23:00
Difficulty: Beginner
Description: Experiment with protein design! We've disabled many of the restrictions in normal Science puzzles, so players have access to all protein designs tools, and may insert and delete any number of residues. Foldit scientists do not check the solutions from this puzzle, and playing this puzzle will not affect your global or category rankings.

Two common protein design Objectives are available, but they will not award any bonuses or penalties. The Core Existence Objective checks to see if 30% of residues are buried in the protein core, away from the water surrounding the protein. The Ideal Loops Objective looks for loops with problematic backbone folds. If you build an especially large protein, try disabling these Objectives to improve Foldit's performance.
Categories:

Top Groups

RankGroupScorePoints
1Contenders40,013
2Gargleblasters37,119
3Beta Folders32,499
4Russian team25,112
5Go Science22,060
Show all >

Top Evolvers

RankPlayerGroupScorePoints
1Bletchley Park 15 25 Contenders40,013
2CharlieFortsCon... 11 21 Contenders38,607
3LociOiling 9 4 Beta Folders30,323
4borattt 67 111 Go Science21,732
5BlueEqualsRed 101 331 Go Science21,521
Show all >

Top Soloists

RankPlayerGroupScorePoints
1CharlieFortsCon... 11 21 Contenders38,423
2LastAndroid 30 32 Gargleblasters37,119
3pvc78 113 44 Beta Folders32,499
4Miguelan15 113 2760  31,466
5snowleopard94 113 602  28,135
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Comments

Sun, 03/22/2020 - 23:30
#1
S0ckrates 113 699
S0ckrates's picture
User offline. Last seen 1 week 5 days ago. Offline
Joined: 05/19/2017
Groups: None
About time!

I was wondering when something like this would turn up. Glad to see an unrestricted proving ground for future projects.

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  • 1
Mon, 03/23/2020 - 07:42
#2
KALYPSO 113 2760
KALYPSO's picture
User offline. Last seen 26 weeks 5 days ago. Offline
Joined: 03/09/2020
Groups: None
Soap

Soap,,,,breaks the faty around the cell ,,,hmmmmm,,,puzzle that,,,just saying,,,try it

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  • 0
Tue, 09/01/2020 - 22:04
#3
Batz 112 110
Batz's picture
User offline. Last seen 3 weeks 3 days ago. Offline
Joined: 02/16/2012
Groups: Go Science
strange wiggle behavior

I don't know what is / I did wrong, but I designed a fold - perfectly fine, but after a while I wiggled, and one part of the protein will start to unfold (the helix is not a helix anymore) and the score goes down instead of up.
I sent the structure to scientists - if you could reproduce that behavior would be interesting! :)

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  • 0
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons