puzzle picture
Protein Design Sandbox
Status: Active

Summary

Name: Protein Design Sandbox
Status: Active
Created: 03/22/2020
Points: 0
Expires: 03/29/2025 - 23:00
Difficulty: Beginner
Description: Experiment with protein design! We've disabled many of the restrictions in normal Science puzzles, so players have access to all protein designs tools, and may insert and delete any number of residues. Foldit scientists do not check the solutions from this puzzle, and playing this puzzle will not affect your global or category rankings.

Two common protein design Objectives are available, but they will not award any bonuses or penalties. The Core Existence Objective checks to see if 30% of residues are buried in the protein core, away from the water surrounding the protein. The Ideal Loops Objective looks for loops with problematic backbone folds. If you build an especially large protein, try disabling these Objectives to improve Foldit's performance.
Categories:

Top Groups

RankGroupScorePoints
1Contenders40,013
2Gargleblasters37,119
3Beta Folders32,499
4BOINC@Poland29,493
5Go Science25,493
Show all >

Top Evolvers

RankPlayerGroupScorePoints
1Bletchley Park 13 40 Contenders40,013
2CharlieFortsCon... 37 32 Contenders38,618
3LociOiling 6 3 Beta Folders30,323
4zo3xiaJonWeinberg 80 123 Go Science25,493
5Hollinas 43 755 Go Science22,000
Show all >

Top Soloists

RankPlayerGroupScorePoints
1CharlieFortsCon... 37 32 Contenders38,435
2akaaka 87 15  38,144
3LastAndroid 87 1969 Gargleblasters37,119
4pvc78 87 1969 Beta Folders32,499
5Enzyme 52 8 Gargleblasters32,421
Show all >


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Comments

Sun, 03/22/2020 - 23:30
#1
S0ckrates 87 1969
S0ckrates's picture
User offline. Last seen 8 weeks 5 days ago. Offline
Joined: 05/19/2017
Groups: None
About time!

I was wondering when something like this would turn up. Glad to see an unrestricted proving ground for future projects.

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  • 1
Mon, 03/23/2020 - 07:42
#2
KALYPSO 87 1969
KALYPSO's picture
User offline. Last seen 1 year 4 weeks ago. Offline
Joined: 03/09/2020
Groups: None
Soap

Soap,,,,breaks the faty around the cell ,,,hmmmmm,,,puzzle that,,,just saying,,,try it

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  • 0
Tue, 09/01/2020 - 22:04
#3
Bautho 64 41
Bautho's picture
User offline. Last seen 1 day 18 hours ago. Offline
Joined: 02/16/2012
Groups: Go Science
strange wiggle behavior

I don't know what is / I did wrong, but I designed a fold - perfectly fine, but after a while I wiggled, and one part of the protein will start to unfold (the helix is not a helix anymore) and the score goes down instead of up.
I sent the structure to scientists - if you could reproduce that behavior would be interesting! :)

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons