puzzle picture
Protein Design Sandbox
Status: Active

Summary

Name: Protein Design Sandbox
Status: Active
Created: 03/22/2020
Points: 0
Expires: 03/29/2025 - 23:00
Difficulty: Beginner
Description: Experiment with protein design! We've disabled many of the restrictions in normal Science puzzles, so players have access to all protein designs tools, and may insert and delete any number of residues. Foldit scientists do not check the solutions from this puzzle, and playing this puzzle will not affect your global or category rankings.

Two common protein design Objectives are available, but they will not award any bonuses or penalties. The Core Existence Objective checks to see if 30% of residues are buried in the protein core, away from the water surrounding the protein. The Ideal Loops Objective looks for loops with problematic backbone folds. If you build an especially large protein, try disabling these Objectives to improve Foldit's performance.
Categories:

Top Groups

RankGroupScorePoints
1Anthropic Dreams46,086
2Contenders40,013
3Gargleblasters37,119
4Beta Folders32,499
5BOINC@Poland29,493
Show all >

Top Evolvers

RankPlayerGroupScorePoints
1Bletchley Park 10 36 Contenders40,013
2CharlieFortsCon... 39 77 Contenders38,618
3LociOiling 4 1 Beta Folders30,323
4zo3xiaJonWeinberg 70 111 Go Science25,493
5toshiue 1 38 Go Science22,397
Show all >

Top Soloists

RankPlayerGroupScorePoints
1phi16 11 30 Anthropic Dreams46,086
2akaaka 70 18  45,864
3CharlieFortsCon... 39 77 Contenders38,435
4LastAndroid 70 1877 Gargleblasters37,119
5pvc78 70 1877 Beta Folders32,499
Show all >


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Comments

Sun, 03/22/2020 - 23:30
#1
S0ckrates 70 1112
S0ckrates's picture
User offline. Last seen 6 weeks 4 days ago. Offline
Joined: 05/19/2017
Groups: None
About time!

I was wondering when something like this would turn up. Glad to see an unrestricted proving ground for future projects.

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  • 1
Mon, 03/23/2020 - 07:42
#2
KALYPSO 70 1877
KALYPSO's picture
User offline. Last seen 1 year 31 weeks ago. Offline
Joined: 03/09/2020
Groups: None
Soap

Soap,,,,breaks the faty around the cell ,,,hmmmmm,,,puzzle that,,,just saying,,,try it

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  • 0
Tue, 09/01/2020 - 22:04
#3
Bautho 70 90
Bautho's picture
User offline. Last seen 6 days 11 hours ago. Offline
Joined: 02/16/2012
Groups: Go Science
strange wiggle behavior

I don't know what is / I did wrong, but I designed a fold - perfectly fine, but after a while I wiggled, and one part of the protein will start to unfold (the helix is not a helix anymore) and the score goes down instead of up.
I sent the structure to scientists - if you could reproduce that behavior would be interesting! :)

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons