bkoep's picture
User offline. Last seen 2 hours 48 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Residue Count (max +550)
Penalizes extra residues inserted beyond the starting 194, at a cost of 55 points per residue. Players may use up to 204 residues in total.

Core Existence (max +2400)
Ensures that at least 28 percent of residues are buried in the core of the monomer unit.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

frood66's picture
User offline. Last seen 3 hours 47 min ago. Offline
Joined: 09/20/2011
Groups: Marvin's bunch
Hallelujah! I will have to

Hallelujah!

I will have to start again - but at last we apparently have what we need!

Thx

NinjaGreg's picture
User offline. Last seen 2 hours 19 min ago. Offline
Joined: 05/21/2010
Groups: Go Science
Thank you!

The change you made to the fixed helix helped me get my non-ideal loops banished to the never-land! It is *much* easier to accomplish this, and not have that one niggling red near the cut-point. Nice work!

LociOiling's picture
User offline. Last seen 1 hour 20 min ago. Offline
Joined: 12/27/2012
Groups: Beta Folders
What's the deal with segment 147?

It has different coloring than the rest of the design part, regardless of the coloring option. In "Hydro" coloring, it's kind of purple. The backbone and the sidechain of segment 147 isn't locked.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons