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1814b: Coronavirus Binder Design: Round 4
Status: Closed

Groups

RankGroupScorePoints
1Go Science14,8160
2Beta Folders14,7290
3Void Crushers14,6570
4Anthropic Dreams14,6430
5Gargleblasters14,4900
6Contenders14,2760
7Marvin's bunch14,1170
8Hold My Beer13,9550
9Cannabis Crew13,3030
10FoldIt@Netherlands13,1320
11L'Alliance Francophone13,0960
12Russian team12,8440
13Minions of TWIS12,3620
14foldeRNA11,9010
15BOINC@Poland11,6460
16Rechenkraft.net11,1720
17DSN @ Home00


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bkoep's picture
User offline. Last seen 11 hours 16 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Objectives

Residue Count (max +550)
Penalizes extra residues inserted beyond the starting 194, at a cost of 55 points per residue. Players may use up to 204 residues in total.

Core Existence (max +2400)
Ensures that at least 28 percent of residues are buried in the core of the monomer unit.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Joined: 09/24/2012
Groups: Go Science
Unideal locked loops?

When checking on the end locked loops from the given binding helix, I don't find ABEGO (Rama) realistic loops for segments 146 and 168.

Is that intended?

The very very low probability I find is Threonine for the 169 and glycine for the 146, both almost red (helix).

I've the impression that it will be difficult if not impossible to find an ideal loop on both sides of this helix (I found one on one side, but it crashed the SS backbones).

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