Hi, first I have to say I love the idea of this game and its pretty fun. I've been playing it for a short while and my impressions on it are that it's fun and making science this way is genius but the user interaction is kinda hard to get used to.
I come from a community of people who are kinda addicted to this kind of puzzle in its own way but dont know they are the blender-comunity and 3D artists in general.
3D artists have to invest lots and lots of time training their spatial reasoning because 3D modeling, is really hard.
I would go as far as to say that foldit as a game is as hard as another puzzle 3D artists have to solve: retopology.
I'm saying this because I suspect that the blender community in special is enthusiastic and hopeful enough to love playing this game provide part of their brainpower and hardware processing power to help science. but there's a catch: foldit is not blender and their interfaces are completely different.
One of my biggest struggles with foldit as a long time bledner user is that its UI is hard for me, not because its bad but because its too different for my 3D modelers' muscle memory to internalize.
I think a good solution for this would be to add external software communication to fold it. If the game could communicate with python, simple data like querrying scores, getting and uploading back protein shape, running wiggle, shake, etc from python, or a simple command line interface, it would be enough for me to make a blender addon that would allow using 3D modeling tools from blender to modify proteins and have foldit validate it.
I am sure that being able to design proteins and relp do science from within blender... these people would go crazy.