puzzle picture
Beginner Puzzle (<150): Coronavirus
Status: Closed

Summary

Name: Beginner Puzzle (<150): Coronavirus
Status: Closed
Created: 03/03/2020
Points: 100
Expired: 04/15/2020 - 23:00
Difficulty: Beginner
Description: Design a protein binder against coronavirus! The starting structure shows how the coronavirus spike protein binds to a human receptor protein. The coronavirus protein (in gray) is mostly frozen, except for the orange and blue sidechains at the binding site. The binding site of coronavirus sticks to the human protein (in color), and this allows the coronavirus to infect human cells. We want to design a new protein that can bind to coronavirus more tightly than the human protein! A tight binder could block the normal coronavirus-human interaction, and might be used as an antiviral drug against coronavirus! Refold and mutate the starting structure to increase your score and improve binding against coronavirus!

START HERE:

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864
_____________________________

If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :
- try all puzzles not only "Beginners" ones,
- fold first the ones you like the most,
- try it by yourself to understand what works and what doesn't,
- ask for tips in global chat when you think you don't understand something.

Categories: Beginner

Top Groups

RankGroupScorePoints
16Trinity Biology13,31850
17Minions of TWIS13,29147
18xkcd13,27745
19Russian team13,22343
20Freedom Folders13,21341

Top Soloists

RankPlayerGroupScorePoints
16ichwilldiesennamen 22 10  13,655100
17pangaena 45 1438  13,650100
1841722114 45 1438 SHELL13,610100
19Jester_sunday 45 1438  13,588100
20RichardH 45 1438  13,57799


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Comments

jeff101's picture
User offline. Last seen 2 hours 16 min ago. Offline
Joined: 04/20/2012
Groups: Go Science
Can players load solutions from this into Puzzles like 1808?

Can players load their solutions from this
puzzle into Coronavirus puzzles like 1808?
https://fold.it/portal/node/2008984

bkoep's picture
User offline. Last seen 2 days 8 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
No loading into regular puzzles

The solutions from this Beginner puzzle are incompatible with other non-Beginner puzzles,. Players may not load solutions from this puzzle into other coronavirus puzzles.

Mery64's picture
User offline. Last seen 2 years 8 weeks ago. Offline
Joined: 03/20/2020
Groups: None
dont work

it dont works on macbook

Joined: 03/27/2020
Groups: None
hc3

try adding more hydro bonds to the virus and then mutate

Joined: 03/27/2020
Groups: None
hc3

hydro bonds to attach to the virus then mutate

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons