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Beginner Puzzle (<150): Coronavirus
Status: Closed


Name: Beginner Puzzle (<150): Coronavirus
Status: Closed
Created: 03/03/2020
Points: 100
Expired: 04/15/2020 - 23:00
Difficulty: Beginner
Description: Design a protein binder against coronavirus! The starting structure shows how the coronavirus spike protein binds to a human receptor protein. The coronavirus protein (in gray) is mostly frozen, except for the orange and blue sidechains at the binding site. The binding site of coronavirus sticks to the human protein (in color), and this allows the coronavirus to infect human cells. We want to design a new protein that can bind to coronavirus more tightly than the human protein! A tight binder could block the normal coronavirus-human interaction, and might be used as an antiviral drug against coronavirus! Refold and mutate the starting structure to increase your score and improve binding against coronavirus!


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Categories: Beginner

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jeff101's picture
User offline. Last seen 2 hours 16 min ago. Offline
Joined: 04/20/2012
Groups: Go Science
Can players load solutions from this into Puzzles like 1808?

Can players load their solutions from this
puzzle into Coronavirus puzzles like 1808?

bkoep's picture
User offline. Last seen 2 days 8 hours ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
No loading into regular puzzles

The solutions from this Beginner puzzle are incompatible with other non-Beginner puzzles,. Players may not load solutions from this puzzle into other coronavirus puzzles.

Mery64's picture
User offline. Last seen 2 years 8 weeks ago. Offline
Joined: 03/20/2020
Groups: None
dont work

it dont works on macbook

Joined: 03/27/2020
Groups: None

try adding more hydro bonds to the virus and then mutate

Joined: 03/27/2020
Groups: None

hydro bonds to attach to the virus then mutate

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons