1799: Sketchbook Symmetric Trimer Design: 90 Residues Status: Closed

# Groups

RankGroupScorePoints
1Go Science21,702100
2Anthropic Dreams21,29568
3Contenders20,98144
4Beta Folders20,94527
5Marvin's bunch20,79016
6Gargleblasters20,5919
7Void Crushers20,5195
8Hold My Beer20,2603
9Hun-Magyar Csapat19,9261
10L'Alliance Francophone19,5691
11Team New Zealand17,1261
12FoldIt@Netherlands12,2951
13IBC Käpsele10,6531
14Italiani Al Lavoro01

Offline
Joined: 02/20/2020
Groups: None
How I played this puzzle

That's how I earned 10000 points:
1.Make all the chain into helix and then make it ideal.
2.Pull the chain into whatever shape.
3.Link the chain with its two mirrors and itself with as many rubber bands as possible in whatever ways and then wiggle to let the chain fold into a weird knot.
4.Click mutate and wait a few minutes.
5.Clear all the rubber bands and re-add rubber bands elsewhere, and repeat the steps above. Also try out "auto structures".
I'm new to this game. I don't know how such a random-generated protein will be used. If you have better ways please tell me.

Online
Joined: 09/24/2012
Groups: Go Science
Find help or ideas from recipes

Great start but you should look at the bonusses: you 'll see there that your "monomer core" was not enough. In order to have a better core, cut your helix in 3-4 helices linked with loops of 1-3 and align the helices almost parallelly.

To do this, there are different ways: cut, align (closer and closer maximising the monomer core bonus), close the cuts. Or simply use the BluePrint tool. And/or freeze the helices, band them in order to fold them parallel, wiggle with Behaviour_Wiggle_Power 0.9 or 0.3 untill the Monomer Core bonus is ok.

When it's ok, freeze the all puzzle and continue with banding like you did or moving the 3 monomers together (with a look on the core complex: not too close). The remaining of your strategy is great.

You could have used the following recipe to be inspired for working designs:
https://fold.it/portal/recipe/101066

When you are done with mutate, you could shake, wiggle sidechains, mutate again (all with wiggle power 1). Then unfreeze everything and wiggle with a look on your bonuses. If the bonuses are not ok, undo and try to stabilize more with mutate-shake and wiggle sidechains before to wiggle.

When you are done, try any banding recipe like GAB, Mutate Phobe Pull, banded worm pair etc. And/or AFK or Blue Fuse.

When you feel it's finished, think about turning wiggle power to High Wiggle Power and wiggle again.

Online
Joined: 12/27/2012
Groups: Beta Folders
nice work, helixes rock

Helixes tend to score well, which is why design puzzles often limit how many segments can be in a helix.

You've discovered a variation of the Cynical Helix Ploy, where the rule is "when in doubt, make helixes".

Generally, three helixes parallel to each other is a good way to go. You'd generally use cutpoints and then the move tool to get them lined up. For some reason, four helixes tend to score lower than three, maybe because more segments are in the loops between helixes, where they don't score as well.