1797: CRISPR-Cas Transposase Part II: Electron Density
|Name:||1797: CRISPR-Cas Transposase Part II: Electron Density|
|Expired:||02/14/2020 - 23:00|
|Description:||Fold the transposase protein into a density map! This is a followup to Puzzle 1787: CRISPR-Cas Transposase Part II, now with a cryo-EM density map! Players may load in previous work from Puzzle 1787.
CRISPR-Cas is a mixed complex of RNA and proteins, which work together to make a very precise cut in a cell's DNA. Scientists recently discovered a variant of CRISPR-Cas that coopts a new protein called a transposase. In addition to cutting DNA, the transposase also allows precise insertion of new material into a target DNA strand. This new variant could lead to more efficient gene editing with CRISPR-Cas! New cryoEM experiments have shed some light on the transposase structure, which was previously unknown.
We're asking Foldit players to help solve how this transposase protein folds! The transposase is a large 400-residue protein, so this puzzle only includes residues from the second half of the protein. Likewise, the provided density corresponds to only this half of the transposase protein.
|Categories:||Electron Density, Overall, Prediction|
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